CD8-positive T cells - Latest research and news - Nature
WEBSep 9, 2024 · We have identified a subset of lymph node CD8 + T cells that demonstrate simultaneous stem-like and effector properties and are strongly associated with viral control during SIV and HIV infection.
Hallmarks of CD8 + T cell dysfunction are established within
WEBAug 3, 2023 · Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven by chronic T...
Beyond exhaustion: the unique characteristics of CD8 - Nature
WEB1 hour ago · CD8+ T cells are functionally impaired during chronic HBV infection. Recent findings from preclinical models and studies of chronically infected humans have revealed surprising insights into the ...
CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a ...
WEBNov 15, 2022 · scRNA-seq identifies dynamically modulated metabolic pathways in CD8 + T cells. We next sought to uncover further dynamic metabolic dependencies of CD8 + T cells by adopting an untargeted, metabolic gene-centric approach, exploiting the dynamic cell-state resolution provided by our single-cell data.
CD8 + T cells in the cancer-immunity cycle - Cell Press
WEBOct 10, 2023 · CD8 + T cells are end effectors of cancer immunity. Most forms of effective cancer immunotherapy involve CD8 + T cell effector function. Here, we review the current understanding of T cell function in cancer, focusing on key CD8 + T …
Not-so-opposite ends of the spectrum: CD8 - Nature
WEBJun 17, 2021 · Sharpe and colleagues review salient aspects of CD8+ T cell dysfunction in cancer, chronic viral infections and autoimmunity, with a view of developing new ways to alleviate T cell exhaustion and...
SARS-CoV-2 infection damages CD8+ T cell response - News-Medical.net
WEBMar 22, 2023 · In a recent study published in the journal Immunity, a team of researchers from the United States found that previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections reduce...
Twin study identifies early immunological and metabolic …
WEB6 days ago · The collected antigen-experienced CD8 + T cells (all single CD3 + CD8 + CD4 − lymphocyte events falling outside the CD45RO − CCR7 + population per gate) were subsequently washed by centrifugation in 0.04% BSA (Invitrogen) in PBS solution at 300g for 10 min at 4°C and resuspended according to …
CD8 is down(regulated) for tolerance: Trends in Immunology - Cell …
WEBMay 22, 2024 · The finding that CD8 + T cells downregulate CD8 expression in response to self-antigens in the periphery as well as during ontogeny in the thymus suggests that modulation of CD8 might be a central component of a tolerance mechanism imposed on self-reactive CD8 + T cells.
CD8 + T cell metabolism in infection and cancer - National Center …
WEBCytolytic effector CD8 + T cells help to eliminate pathogens through cytokine secretion and direct killing of infected cells, while long-lived memory CD8 + T cell populations provide enhanced protection from reinfection.