Florence is a city in, and the county seat of, Lauderdale County, Alabama, United States, in the state's northwestern corner, and had a populatio…Florence is a city in, and the county seat of, Lauderdale County, Alabama, United States, in the state's northwestern corner, and had a population of 40,184 in the 2020 census. Florence is located along the Tennessee River and is home to the University of North Alabama, the oldest public college in the state, which makes Florence a college town. Florence is located about 70 miles west of Huntsville, Alabama, via US-72.
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