In their Week 5 matchup on Sunday at 1:00 PM ET, RB Joe Mixon and the Houston Texans match up with the Buffalo Bills, who have the 30th-ranked run defense in the league (165.3 rushing yards allowed per game).

Will Texans RB Joe Mixon get the start for the Texans or will it once again be Cam Akers? Blaine Grisak breaks down what it means for fantasy football.

The Houston Texans will be without star running back Joe Mixon for their matchup against the Jacksonville Jaguars. Mixon has been dealing with an ankle injury that he suffered during Week 2 against the Chicago Bears.