eLife4h
Odors drive feeding through gustatory receptor neurons in Drosophila
In sum, odors initiate feeding behavior in Drosophila.
eLife5h
TopOMetry systematically learns and evaluates the latent dimensions of single-cell atlases
A core task in single-cell data analysis is recovering the latent dimensions encoding the genetic and epigenetic landscapes inhabited by cell types and lineages. However, consensus is lacking for ...
eLife11h
Pain Management: A promising alternative to opioids
A complex extracted from the amniotic membrane in humans reduces post-surgical pain in mice by directly inhibiting pain-sensing neurons.
eLife1h
Variation in thermal physiology can drive the temperature-dependence of microbial community richness
Here we derive a general empirically-grounded theory that can explain this phenomenon by linking microbial species richness in competitive communities to variation in the temperature-dependence of ...
eLife3d
Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer’s disease research
A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).
eLife6d
Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation
Repurposing of a drug designed for pain relief can quickly and reversibly slow biochemical and metabolic activities in cells and organs and could facilitate organ transplantation and prevent tissue ...
eLife4d
The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting
A primary constraint for mitochondrial repression is access to cytosolic inorganic phosphate, which is determined by the glycolytic flux rate.
eLife3d
Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient
A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and ...
eLife5d
Genetic diversity affects ecosystem functions across trophic levels as much as species diversity, but in an opposite direction
This study presents valuable findings from an observational dataset in a riverine ecosystem about the effects of genetic and species diversity, across multiple trophic levels, on ecosystem functions.
eLife6d
Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells
The raw mass spectrometry data was deposited in the PRIDE repository:Project Name: Spatially restricted proteomics reveals dynamic changes in the caveolin-1 interactome in response to increased membra ...
eLife6d
Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice
However, there is a lack of knowledge about how externally applied currents affect neuronal spiking activity in cerebellar circuits in vivo. We investigated how Cb-tDCS affects the firing rate of ...
eLife4d
Reprogramming: A perfect recipe for a corticospinal neuron
A tailored cocktail of genes can reprogram a subset of progenitors to no longer produce glial cells and instead develop into neurons involved in motor control.