IgG4-related disease is a multiorgan, relapsing, fibroinflammatory, immune-mediated disorder with no approved therapy. Inebilizumab targets and depletes CD19+ B cells and may be effective for ...

Lung transplantation has evolved over 60 years from an experimental to an accepted standard treatment for life-threatening lung disease. Suitable recipients can expect improved survival and ...

Obesity is chronic disease and causal precursor to myriad other conditions, including type 2 diabetes. In an earlier analysis of the SURMOUNT-1 trial, tirzepatide was shown to provide substantial ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Dr. Yanki Okuducu (Pediatrics): A newborn girl was admitted to the neonatal intensive care unit (NICU) of this hospital because of cardiorespiratory arrest at delivery. The newborn’s mother was ...

In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and ...

A 44-year-old woman presented to the primary care clinic with a 2-year history of shortness of breath with minimal exertion, cough productive of clear sputum, generalized fatigue, and an ...

In patients with heart failure and secondary mitral regurgitation, both mitral-valve surgery and transcatheter edge-to-edge repair are recommended therapies. New research findings comparing ...

Many patients with moderate to severe functional mitral regurgitation remain symptomatic despite receiving guideline-recommended therapy. New research findings on transcatheter mitral-valve repair ...

Medication abortion, with a combination of mifepristone and misoprostol, is highly effective and safe. However, there is insufficient evidence on efficacy and safety at very early gestations ...

Important adverse events included infusion-related and hypersensitivity reactions in 25 of 306 immunocompromised participants (8.2%) who received pemivibart and anaphylaxis in 4 of 623 ...

In Western countries, perioperative chemotherapy is the standard of care for resectable gastric cancer. Interest has been high in adding preoperative chemoradiotherapy to this treatment.