Kyle Shanahan’s offense has always been able to glean the most ... 5.2. Not having Christian McCaffrey in the lineup most of the season and losing a rusty Brandon Aiyuk to injury played a role there.

After a season filled with seemingly countless injury issues, the San Francisco 49ers may be down another wide receiver.

San Francisco 49ers tight end George Kittle was expected to play a major role in the team's rivalry matchup against the Seattle Seahawks on Sunday afternoon. Ev ...

Kyle Shanahan and the San Francisco 49ers got a very important injury update before the game against the Seahawks. Kyle ...

Create the best lineup on DraftKings for Sunday’s NFL Main Slate of games and take home the million-dollar first prize ...

Seattle pulled even with San Francisco at 5-5 after scoring both of their touchdowns following Nick Bosa's early exit in the ...

Kyle Shanahan praised San Francisco rookie wide receiver Ricky Pearsall's "impressive" comeback after being shot on Aug. 31 ...

The San Francisco 49ers boast one of the deepest WR groups in the league, but they could be ditching one of their best ...

Brandon George picked off a pass from McCord on a third-and-10 at the Syracuse 44. In the second quarter, the third drive also ended with the same result: This time, Kyle Louis returned one for a ...

Left tackle Trent Williams’ ankle and wrist injuries could force him to miss his first 49ers game this season Sunday against ...

The San Francisco 49ers have won back-to-back games since Brandon Aiyuk was lost for the season to a serious knee injury. San ...

The San Francisco 49ers are set to bolster their pass rush ahead of Sunday's game against the Seattle Seahawks. Head coach ...